17th December 2009: Nutrimenthe publication

Congratulations to the Erasmus MC University Medical Center for the first Nutrimenthe publication.   The paper appeared in the British Journal of Nutrition this September.

It is well known that supplementation with folic acid during the first trimester of pregnancy reduces the risk of neural tube defects in the foetus, but there is a lack of information on the association between prenatal folate status and neurodevelopment after neural tube closure.  There are several lines of research that suggest that folate intake during early pregnancy is important for mental development.   

The present study, conducted by Sabine Roza from the Erasmus MC University Medical Centre, examined the effect of folate supplementation during the first trimester of pregnancy on child behaviour at 18 months in 4214 toddlers from the Generation R study. Lack of folic acid supplementation was related to toddlers showing withdrawn behaviour, attention problems and aggressive behaviour.  The study concluded that failure to use folic acid supplements during early pregnancy is associated with child behavioural and emotional problems at 18 months.

Reprints of the paper can be obtained by contacting:  Dr Henning Tiemeier, email




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